| Successful and efficient reproduction in mammals depends, amongst others, on the number and quality of the germ cells which are produced, on properly timed interactions between the gametes, on biochemical characteristics of the internal environment of the genital tract, and on an optimal course of embryonic and foetal development. This research program will therefore focus on communication mechanisms between cells within the gonads, between cells within the oviduct and the uterus, and between cells of the genital tract, the gametes and the conceptus.. For this purpose, biochemical, molecular-genetic, cell-biological and physiological methods will be used, following both in vitro and in vivo approaches. In addition embryonic stem cell lines will be generated to study early differentiation processes. Basic information on crucial steps in the reproductive cycle will also enable the development of tools for the artificial control or modification of gametogenesis, fertilisation, conception and intrauterine development. It will also be investigated if the development, health and reproductive performance of the embryos, foetuses and offspring, obtained with artificial reproductive techniques, are adversely affected. By exploring and evaluating methods to influence reproductive processes in domestic animals, it is aimed to increase the fundamental knowledge of cellular mechanisms involved in reproduction, to increase the efficiency of reproduction, to decrease sub-fertility and infertility, and to preserve valuable genetic potential for the future. In addition, results from the basic and applied research in this cluster may be of use for fertility research in humans. |
