NARCIS provides access to 514,347 scientific publications (204,499 of which are open access publications), 13,905 data sets, and information on researchers (expertise), research projects and research institutes in the Netherlands.
Show page in English/Toon pagina in Nederlands
 
Program: Maturation and interaction of gametes and their consequences for the de...
  • Title (NL) Maturation and interaction of gametes and their consequences for the development of the conceptus
  • Period 2002 - unknown
  • Status Current
Abstract
bullet Abstract Successful and efficient reproduction in mammals depends, amongst others, on the number and quality of the germ cells which are produced, on properly timed interactions between the gametes, on biochemical characteristics of the internal environment of the genital tract, and on an optimal course of embryonic and foetal development. This research program will therefore focus on communication mechanisms between cells within the gonads, between cells within the oviduct and the uterus, and between cells of the genital tract, the gametes and the conceptus.. For this purpose, biochemical, molecular-genetic, cell-biological and physiological methods will be used, following both in vitro and in vivo approaches. In addition embryonic stem cell lines will be generated to study early differentiation processes. Basic information on crucial steps in the reproductive cycle will also enable the development of tools for the artificial control or modification of gametogenesis, fertilisation, conception and intrauterine development. It will also be investigated if the development, health and reproductive performance of the embryos, foetuses and offspring, obtained with artificial reproductive techniques, are adversely affected. By exploring and evaluating methods to influence reproductive processes in domestic animals, it is aimed to increase the fundamental knowledge of cellular mechanisms involved in reproduction, to increase the efficiency of reproduction, to decrease sub-fertility and infertility, and to preserve valuable genetic potential for the future. In addition, results from the basic and applied research in this cluster may be of use for fertility research in humans.
Related organisations
bullet Secretariat Departement Gezondheidszorg Landbouwhuisdieren (UU)
Related people
bullet Project leader Prof.dr. B. Colenbrander
Classification
bullet A22000 Animal husbandry
bullet C10000 Biotechnology
bullet D21300 Biochemistry
bullet D21500 Histology, cell biology
bullet D21700 Physiology
bullet D22100 Microbiology
bullet D22600 Zoology
Update this data in the Dutch Research Database (NOD).