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Prof.dr. J.M. Middeldorp

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Expertise Molecular (DNA,RNA, protein) aspects of virus- and host-related activities relevant for the pathogenesis, diagnosis and treatment of human herpesvirus infections, esp. Cytomegalovirus and Epstein-Barr virus, related to acute and chronic (incl. malignant) diseases in the immunocompetent and immunodeficient host. Basic aspects of antiviral immune reactivity (humoral and cellular)
Expertise (NL) Moleculaire (DNA, RNA, eiwit) aspecten van virus- en gastheer gerelateerde processen die een rol spelen bij de pathogenese, diagnose en behandeling van humane herpesvirussen, met name Cytomegalovirus en Epstein-Barr virus, in acute en chronische (maligne) ziektebeelden in de immunocompetente en immunodeficiënte gastheer. Basale aspecten van anti-virale immuunreactiviteit (humoraal en cellulair)

Active as

Extraordinary professor
Organisation Department of Pathology (VU)
Chair (EN) Molecular immunopathogenesis of Epstein-Barr virus-associated malignancies in man
Chair (NL) Moleculaire immunopathogenese van Epstein-Barr virus geassocieerde maligniteiten bij de mens
Phone +31-20-4444052
Email j. middeldorp -at- vumc. nl

Current research

(the most recent research is at the top)
Project leader Expertise transfer on diagnostic methods in nasopharyngeal carcinoma
Project leader Non-invasive diagnostic and prognostic markers in nasopharyngeal carcinoma
Project leader In situ detection of viral and cellular markers in nasopharyngeal carcinoma
Project leader Epstein-Barr virus and carcinogenesis
Project leader Role of the soluble viral BARF1 oncoprotein in Epstein-Barr virus-driven carcinogenesis and its functional inhibition by antibodies
All current research..

Completed research projects

(the most recent research is at the top)
Supervisor Epidemiology and screening for early-stage detection of Nasopharyngeal carcinoma
Project leader Characterization of BARF1 as a potential target for immunotherapy of Epstein-Barr virus carrying gastric carcinomas.
Project leader LMP1 and LMP2 specific T-cell stimulation and immunotherapy in EBV+ Hodgkin's disease

Classification

D21800 Immunology, serology
D22100 Microbiology
D21300 Biochemistry
D21400 Genetics
A70000 Public health and health care
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